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In a 2019 study, Chen and colleagues (opens in new window) set out to further explore this effect and understand whether this expression pattern also occurs in normal cells in vitro

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And as we learned from the Tips From Former Smokers campaign, this can be corrected

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Some people have slower-acting versions of CYP2A6, which results in nicotine staying in their system for a longer time, while others have more efficient variants that break down nicotine more quickly