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One NIH Study found moderate evidence of a statistical association between cannabis use and the development of substance dependence and/or a substance abuse disorder for substances, including alcohol, tobacco, and other illicit drugs. Addiction within the family, especially during early childhood, may also cause a person to develop an addiction

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Studies using transdermal patches in non-smokers confirm that nicotine increases alertness while improving both EEG measures and self-rated feelings of wakefulness