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While Gemcitabine offers a survival benefit both as a monotherapy and in combination with other medications, these responses are seldom complete, and nearly all tumors display or will develop some degree of Gemcitabine resistance, with only 4% of patients surviving two years on Gemcitabine alone ( As discussed, the main method of Gemcitabine uptake is via the hENT1 transport protein

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In the United States, they have been reported in parts of New York State, Maine, Pennsylvania, Vermont, and parts of Ohio

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