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doi: 10.1038/nature25465 19 SircarKHuangHHuLCogdellDDhillonJTzelepiVet al
88,100,140,141 However, some studies have also found that CHD8 is a positive regulator of the Wnt/-catenin signalling pathway in NPCs and negatively regulates this pathway in nonneuronal cell lines, suggesting that CHD8 may regulate Wnt signalling in a cell-specific manner
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Frohlich J, Senturk D, Saravanapandian V, Golshani P, Reiter LT, Sankar R, et al
They become part of a longevity-focused plan, not just a weight loss plan
However, in a randomized phase III double-blind clinical trial, tivantinib did not improve OS time in patients with Met-high advanced HCC treated with sorafenib compared with placebo (Rimassa et al., 2018) (NCT01755767)
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