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Below is a list of the significant transmitters that are released by nicotine and their subsequent effects: In the brain, activation of excitatory presynaptic nicotinic receptors results in a wide range of central effects ranging from relief of anxiety, regulation of mood, and changes in appetite, alertness, and cognition

New Engl J Med 381:14861487 Layden JE, Ghinai I, Pray I et al (2019) Pulmonary illness related to e-cigarette use in Illinois and Wisconsin - preliminary report

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Their parents also have a restless night ahead, and they may worry that something more serious might be causing the symptoms