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Carnitine plays an important role in transporting fatty acids into the mitochondrial matrix via the carnitine/acylcarnitine shuttle where occurs -oxidation, acetate is produced and is utilized to generate energy in the TCA cycle

In these antioxidant reactions, glutathione is oxidized to form the oxidized disulfide form, GSSG which is then, in turn, reduced back to glutathione using NADPH.[ref] Mitochondria are essential for the production of ATP for energy storage in cells

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We observed that more than one-third of metabolites detected in heart were significantly altered with aging, which was predominantly characterized by a rise in the level of glycerophospholids, and to a lesser extent, acylcarnitines (Fig