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According to the Centers for Disease Control and Prevention, it has myriad of negative effects, from nicotine addiction to cancer of the mouth, esophagus and pancreas

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Warning notices must therefore also be affixed

So, I recommend exercise indoors when air quality is bad, or if one cant exercise indoors, wear a mask to reduce the dose of inhaled PM2.5

Over Some people wear their patches continually and have a steady dose of nicotine over 24 hours, while others remove them at night

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