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In clinical trials: Semaglutide: Approximately 7% discontinued due to adverse events Tirzepatide: Approximately 4-7% discontinued due to adverse events (dose dependent) Retatrutide: Approximately 6-10% discontinued due to adverse events (dose dependent) These rates are relatively close, suggesting that despite the differences in mechanism and side effect profiles, all three medications are tolerable for the vast majority of people who start them

DOSAGE AND ADMINISTRATION

Manufacturing precision determines whether each vial contains exactly 5 mg, 10 mg, or 15 mg of tirzepatide

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If you ever need to adjust them, the route should be two clicks, not ten