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BPC-157's gastroprotective properties have theoretical appeal alongside semaglutide, given that GI side effects are semaglutide's most common adverse event

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Most notably, the FLOW trial, the first dedicated GLP-1 RA kidney outcome trial, demonstrated that once-weekly semaglutide reduced the risk of sustained decline in estimated glomerular filtration rate (eGFR), kidney failure or cardiovascular death in people with CKD and T2D [9]

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Specific bacterial strains influence GLP-1 secretion from enteroendocrine cells

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