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In these trials, significant weight loss was demonstrated with liraglutide 3.0 mg therapy, compared to placebo (8.0% in SCALE obesity and prediabetes, 6.0% in SCALE-diabetes)

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Diabetes-induced glucose metabolism disorders have a profound impact on spermatogenesis through multiple mechanisms, including lipid metabolism abnormalities, changes in epigenetic modifications, mitochondrial dysfunction, and glycolysis abnormalities [67, 160, 216]

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