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In addition, the non-GAAP measures of adjusted gross profit, adjusted gross margin, adjusted profit from operations, adjusted operating margin, New Categories contribution, New Categories contribution margin, adjusted net finance costs, adjusted taxation and adjusted diluted earnings per share, are presented with the additional adjustment to reflect the settlement of the Canadian litigation, and are referred to as "as adjusted for Canada" (as discussed above)

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Single-cell RNA-sequencing The normal liver and chronic hepatitis B single-cell datasets were downloaded from the GEO database

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