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Despite decades of accumulated epidemiologic and experimental evidence on the causal relationship between tobacco smoking and lung cancer and other diseases, as well as significant progress achieved in reducing tobacco use globally since the adoption in 2005 of the WHOs Framework Convention on Tobacco Control (FCTC) , smoking remains one of the largest causes of preventable disease and death, with nearly 80% of the worlds one billion smokers living in developing countries

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[DOI] [PMC free article] [PubMed] [Google Scholar] Polzin GM, et al