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Tambin se ha observado alteraciones en el metabolismo del glutatin en enfermedades psiquitricas como la esquizofrenia , en desrdenes neurolgicos agudos como la isquemia cerebral y en procesos fisiolgicos como el envejecimiento

[PMC free article: PMC1683844] [PubMed: 2339702] 250

The deficiency of Nrf2 in Nrf2 knockout (KO) mice attenuated the chondroprotective effect of metformin on OA development, further affirming the core position of Nrf2 signaling during metformin fights illness as an antioxidant

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doi: 10.1016/j.neuroscience.2018.01.001