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But there are problems with so-called specificity, meaning there are other reasons values can be abnormal, like diminished kidney function in the case of MMA, and folate deficiency in the case of homocysteine

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2015 Nov;30(13):1831-7

However, prolonged use of painkillers has led to the development of opioid addiction, which has been linked to the reward processes, one of the primary functions of opioids (Pellissier et al

Severe glutathione synthetase deficiency Patients have symptoms as in moderate glutathione synthetase deficiency and, in addition, they develop progressive neurological symptoms, e.g