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Despite the many actions taken at the federal, state and local levels across the United States, concerns about a new generation addicted to nicotine products continue to compel policymakers, school officials, public health officials and other stakeholders to work collaboratively to reduce the use of e-cigarettes.

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Overall, even if the product development efforts for SPREE BAR as a nicotine analog product did not begin with tobacco-industry based knowledge of the work of Haglid et al., there has likely been wide acquaintance with the UCSF collection within the electronic nicotine delivery system (ENDS, e-cigarettes) industry