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In contrast, late eating acts as a potent chronodisruptive cue for peripheral clocks, leading to circadian misalignment that interferes with melatonin-mediated synchronization

These changes are typically related to the weight loss process itselfincluding dietary modifications, dehydration from gastrointestinal side effects, or mild ketosisrather than a direct pharmacological effect of the medication

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Data were corrected for baseline and vehicle (probe only) responses

PubMed Neves JS, Leite AR, Vale C, et al