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The Pro-KIV 1.01 software (Applied Photophysics) was used to perform kinetic simulations of the mechanistic models using the determined rate constants from Table 1 based on the indicated reaction schemes

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Through AdipoR1- amp-activated protein kinase (AMPK) signaling, adiponectin shifts microglia toward the anti-inflammatory M2 phenotype, ameliorating neuroinflammation and depressive behaviors in chronic stress models (157)

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This dual-agonist approach amplifies GLP-1 and GIP signaling simultaneously, which can enhance weight loss and metabolic control compared to either compound alone