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While appropriate engagement of well-regulated stress responses is central to the maintenance of physiological homeostasis, the persistent induction of unresolving BCEV-induced stress, particularly in smokers or E-cigarette users, may eventually be maladaptive in a manner that is ultimately conducive to tissue damage and/or recipient cell transformation

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By comparison, 26% of respondents said they had smoked a cigarette in the prior week in 2003 and 38% in 1983

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