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45, 46 A detailed analysis of the inflammatory infiltrates in a mouse model of chronic obstructive pulmonary disease (COPD) revealed that DC numbers in the airways raised gradually after a short period of continual smoking, reaching 10-fold levels after a chronic exposure for 6 months compared with the numbers in sham-exposed animals

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A randomized crossover study of occasional tobacco cigarette users demonstrated an acute increase in vascular stiffness after inhaling e-cigarettes with and without nicotine, as evidenced by increased AI75 (pulse wave augmentation index at 75%) and PWV (pulse wave velocity) (24)

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