Numerous studies have shown that the upregulation of NOXs in vascular tissues and cell types such as endothelial cells, smooth muscle cells, fibroblasts, and others plays a key role in atherogenesis by promoting endothelial dysfunction and vascular inflammation
( Image courtesy of Gogtay, with permission .) The human brain is not fully mature until the mid-20s, thus leaving teenagers more vulnerable to developing a nicotine addiction
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