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Oral formulations of GLP-1 medications, including oral semaglutide drops and sublingual semaglutide , may produce different gastrointestinal side effect patterns compared to injectable formulations

Understanding these potential side effects is essential for informed decision-making by healthcare providers and patients, as well as for appropriate monitoring and management strategies during treatment

Nausea is most common early in treatment or after dose increases, especially if meals are large, fatty, or eaten quickly

No, semaglutide that has been frozen should be discarded immediately

They're close to the results seen in the STEP 1 trial, where participants lost 15% of their starting weight on average with injectable semaglutide

Ondansetron is sometimes prescribed short-term during dose escalation