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International Smuggling and Counterfeiting Hurts Americans Smuggling that occurs within the borders of the United States is mostly a zero-sum activity from a cost perspective, and smugglers may even facilitate an increase in total economic activity by decreasing the market tax burden, albeit at unacceptably high social costs (not to mention the innate criminal nature of the activity)

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No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out

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