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92 Data from diabetes trials indicate that lixisenatide can improve liver transaminases, especially ALT

Rizvi AA, Rizzo M (2022) The emerging role of dual GLP-1 and GIP receptor agonists in glycemic management and cardiovascular risk reduction

Retatrutide is the most talked about next generation option, targeting three hormone pathways instead of one or two

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It works on both GLP-1 and GIP receptors, while Wegovy acts on GLP-1 only

Liver Enzyme Interactions Berberine is processed by the liver using specific pathways (specifically the CYP450 enzymes)