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In terms of technology, the industry is witnessing an historic shift towards the adoption of next-generation nicotine delivery systems

[7] After the implementation of Directive 1010.10 in 1986, the Tobacco Institute and Philip Morris immediately began seeking the support of tobacco-friendly politicians against the policy, citing that the policy would have a negative impact on military recruitment, retention, and morale

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Specifically, one 1R6F standard research cigarette (Kentucky Tobacco Research & Development Center, Lexington, KY, USA) was smoked per cycle (one cycle in total), with a puff volume of 55 mL, a puff duration of 2 s, a puff interval of 30 s, and a puff exhaust time of 8 s (Fig

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