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Experimental studies have demonstrated that supplementation with Lactobacillus strains or specific postbiotics can restore intestinal barrier integrity, reduce lipopolysaccharide (LPS) translocation to the liver, lower systemic inflammation, and attenuate hepatic steatosis (75, 76)

For lupus patients, those that improve mitochondrial function or reduce inflammatory burden are most likely to address the root causes of fatigue rather than simply providing temporary stimulation

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