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Non-tobacco materials: These include cigarette papers and filters

Co-delivery of Silymarin and Metformin dual-loaded in mesoporous silica nanoparticles synergistically sensitizes breast cancer cell line to Mitoxantrone chemotherapy

Teresi JA, Yu X, Stewart AL, Hays RD

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In the absence of modern amenities, such as toothbrushes and toothpaste, chewing tobacco was also seen as a rudimentary way to maintain oral hygiene

Further, MMP12 deficiency dysregulated fewer genes among MMP12 KO mice exposed to JUUL + HDM compared WT JUUL + HDM (61 WT vs 37 KO) (Additional file 1: Table S2)