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4.3 Colonization and host interaction Therapeutic implementation also faces difficulties with reliable colonization, dosage control, strain-to-strain variation, and effective host interaction (Suez et al., 2019)

However, despite this decline, several countries still have alarmingly high smoking rates, with nearly half of their populations continuing to smoke

Nicotine affects the nervous system, raises blood pressure, increases heart rate, and alters the release of hormones such asinsulin and cortisol

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