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While scientists can hypothesize what health effects might occur in people who use pouches, some areas of uncertainty wont be cleared up until long-term studies are done

Additionally, chronic tobacco use leads to changes in brain structure and function, particularly in regions involved in decision-making, impulse control, and emotion regulation

Is there any science behind that

The answer is yes

"We can now say that these chemicals are found in the body of human adolescents who use these products." The chemicals are not listed on the ingredients of the vape liquid

The DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition) identifies tobacco use disorder with criteria including cravings, difficulty reducing usage, and withdrawal symptoms like anxiety and restlessness when nicotine intake is reduced