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In conclusion, our findings indicate that metformin may alleviate OA pain and partially attenuate the pathological changes associated with OA, suggesting a potential protective role

Gene Ontology analysis (GO) of these DEGs further revealed significant enrichment of terms associated with plant defense signaling, including defense response, cellular responses to JA, response to wounding, and response to hormone (Fig

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Bard, J

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Similar to rapamycin 31 , these effects were achieved even though not initiated until later in life, which we reasoned to be a safer therapeutic window for IGF-1R modulation than younger ages 34