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Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival

[99] For comparison, populations with high levels of smoking can have a lung cancer incidence of over 1,000 per 1,000,000

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Specifically, nicotine and its primary metabolite cotinine are metabolized by the uridine 5-diphospho-glucuronosyltransferase (UGT) superfamily enzymes: specifically UGT2B10 for nicotine and cotinine, and UGT2B7, UGT2B15, and UGT2B17 are responsible for metabolizing androgens

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