Antimicrobial responses to enteric pathogens are also modulated by commensal gut colonising bacteria
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Berberine inhibits neuronal apoptosis by regulating autophagy-related proteins [Microtubule-associated protein 1A/1B-light chain 3 (LC3), Beclin-1, p62], and apoptosis regulatory proteins [caspase 3, caspase 8, caspase 9, poly ADP-ribose polymerase (PARP), and B-cell lymphoma 2 (Bcl-2)/Bcl-2 associated X (Bax)] (Zhang et al., 2016)
Future research should differentiate between symptomatic and asymptomatic infected individuals, select specific probiotics or their fermented products, utilize widely studied strains, standardize experimental protocols (including dosage, duration, and clinical endpoints), and assess the long-term effects of probiotic interventions
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