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Peer pressure, social and economic circumstances, parental attitudes, laws and the price of substances are all likely to affect whether or when a teenager starts to use tobacco, cannabis or alcohol

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This single factor accounted for a large negative contribution of 290.54% (p=0.007) to the total AQSLT change

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BATs shares, the biggest gainers in the FTSE 100 index this year, initially rose before closing down nearly 3% at 46.66, despite a strong trading update for the first nine months

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