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The primary outcome will be biochemically verified continuous vaping abstinence at the end of the treatment (week 12)

Both may contain nicotine as the e-liquids used in vaping come in various nicotine strengths, which allow someone who has smoked nicotine-containing tobacco cigarettes to switch over and gradually reduce their intake over time

Additional safety advice is also included below

In lung epithelial cells, cigarette smoke increases total cellular poly-ubiquitinated proteins [17], which is consistent with our findings (Fig

cytotoxic, mutagenic and proinflammatory substances contained in cigarettes Surfactant smoking is associated with reduced surfactant phospholipids fibrotic factors T helper type 1 (Th1) cells are a lineage of CD4 + effector T cell that promotes cell-mediated immune responses and is required for host defense against intracellular viral and bacterial pathogens

Currently minors can legally purchase white snus pouches, since there is currently no legal minimum age to buy nicotine pouches in the UK