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4, 5, 6, 7, 10, 11, 12 Although for each pack-year smoked, the cortex is only very slightly thinner than in subjects who never smoked, this rate of smoking-related thinning is approximately twice that of a previously observed yearly rate of mean cortical thinning in typical adult populations

Each year, more than 480,000 people in the United States die from tobacco-related illnesses

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