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Variations in study designs, such as cross-over versus parallel designs, and differences in endpoints measured also influenced the results (23, 33, 41)

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In July 2020, the FDA authorized Philip Morris to market IQOS, another one of the devices available in Japan, as a modified risk product in the States

Statistical Analysis Sensitivity and specificity of the 2021 USPSTF guideline versus proposed guideline were calculated for each study cohort

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