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SLC7A11 can reduce lipid peroxidation accumulation and prevent cells from entering the ferroptosis program by introducing cysteine and promoting GSH synthesis (67)

In lung cancer, particularly NSCLC, reduced GAS5 expression is associated with advanced TNM stage and larger tumor volume

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Ilic S, Drmic D, Zarkovic K, Kolenc D, Coric M, Brcic L, et al

We then overexpressed GCLC in cells with ACTL6A knocked down and found that GCLC reversed the inhibition of cell proliferation (Fig

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