For clarity, the evidence discussed below can be grouped into three levels: (1) direct experimental evidence, in which mitochondrial danger signals or mitophagy-related mechanisms are directly linked to distant-organ injury
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140 Esther, The Autobiography , p
The data implied that while smoke exposure induced microbiota disruption and emphysema, structural lung damage alone did not maintain the altered microbiota, indicating that microbial shifts might not directly contribute to emphysema progression [86]