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It's the body's way of signaling that it can't handle the amount of nicotine it's been exposed to

It is well known that tobacco companies, in the 1960s and 70s, targeted menthol cigarettes to African American communities, and menthol cigarettes became ubiquitous in those communities, said David Mendez, lead author of the study and an associate professor in the Department of Health Management and Policy at the U-M School of Public Health

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The activation and/or upregulation of many xenobiotic metabolism enzymes is driven by exposure to chemicals that can serve as substrates

But researchers have amassed a rapidly increasing body of knowledge linking these genetic variants to tobacco addiction, responses and disease." Genetic research on tobacco dependence has blossomed in recent years

Early course of nicotine dependence in adolescent smokers