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"They'll end up getting more than $2 billion in reputational capital and kudos," Dartmouth professor Paul Argenti tells Shots

however, small sample sizes and statistical biases limit this evidence

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There have been questions as to whether varenicline can cause symptoms of depression, suicidal thoughts, agitation, and aggression, though research suggests that while all of these problems can occur when people try to quit smoking, none of them occur more frequently among people taking varenicline than those assigned placebo