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For primary and secondary endpoints based on DEXA measurements, scans were obtained within 7 days prior to participants initial dose of apitegromab or placebo and were repeated at 24 weeks

The 2024 NICE guideline asks clinicians to tailor timing to your symptoms and review it, rather than treating one figure as fixed

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Importantly, formulations add further steps

Future research should focus on validating these benefits in animals and clinical trials and developing optimized formulations for clinical application