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Our analysis indicates that pathways related to energy metabolism (e.g., fatty acid metabolism, mitochondrial electron transport chain, TCA cycle) and amino acid metabolism (e.g., branched-chain amino acids, phenylalanine, tyrosine, and tryptophan) were particularly affected

In the context of nanomaterials, factors such as particle size, dosage regimen, administration route, surface chemistry, degree of aggregation, transmembrane diffusivity, excretion mechanisms, and immunogenic potential are the key determinants of nanotoxicity

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A 2020 systematic review in the Journal of the American Academy of Dermatology (N=634 across 8 studies) found that oral minoxidil at doses ranging from 0.25 mg to 5 mg daily produced clinically meaningful hair density improvements in 60% to 82% of patients over 6 to 12 months [3]