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Activation of TRPA1 on C-fibers stimulates the release of neurokinin A (NKA), substance P (Sub P), and calcitonin gene-related peptide (CGRP)
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Family Smoking Prevention and Tobacco Control Act (FSPTCA) embraces the concept of THR and defines a modified risk tobacco product (MRTP) as any tobacco product that is sold or distributed for use to reduce harm or the risk of tobacco-related disease associated with commercially marketed tobacco products [8]
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The background section says existing heated-tobacco systems weaken one of the traditional cigarettes social functions because sticks depend on a dedicated holder and therefore cannot be casually shared like traditional cigarettes. The patent repeatedly presents its integrated format as a way to restore that pattern
PMID 26463545
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