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2 Design logic of multifunctional nanotherapies targeting the tumor microenvironment 2.1 Key tumor microenvironmental barriers and corresponding design objectives The tumor microenvironment features that shape drug delivery and therapeutic response in solid tumors can be grouped into three levels that are particularly relevant for nanomedicine design, namely the vasculature and interstitium, the extracellular matrix, and the immune compartment [29,30,31]

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