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Chatterjee et al ., Reference Chatterjee, Tao, Johncola, Guo, Caporale, Langham and Wehrli2019

Smokeless tobacco's digestive effects may result from: Higher nicotine absorption rates than cigarettes Longer duration of use (pouches often remain in place for 30-60 minutes) Additional compounds in tobacco that affect digestive functioning Historically, tobacco leaf preparations have been used for their laxative effects, suggesting this digestive response has been known for centuries

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Chronic lower respiratory disease a catch-all term for emphysema, chronic obstructive pulmonary disease (COPD), chronic bronchitis, and asthma is the third leading cause of death globally

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