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The overall pattern and frequency of adverse events during the longer-term premarketing trials was similar to those described in Table 1, though several of the most common events were reported by a greater proportion of patients with long-term use (e.g., nausea was reported in 40% of patients treated with CHANTIX 1 mg twice daily in a one year study, compared to 8% of placebo-treated patients)

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A representative from a tobacco firm, who did not want to be identified, said that many tobacco companies are surprised by the announcement, because they had highlighted when being consulted on the matter that this plain packaging policy had not been effective in the few countries where it is in place