Therefore, while cost remains an important consideration, the other factors at play are more crucial
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Finally, at the top is regulatory approval and post-market surveillance, where a therapy has demonstrated sufficient safety and effectiveness to be formally approved, and its long-term risks are continuously monitored
Therefore, in this study, we have used human hepatoma HepG2 cancer cells, a commonly used cell culture model, which has been treated with buthionine sulfoximine (BSO), a GSH depleting agent and N-acetylcysteine (NAC), a precursor of GSH synthesis, to study the implications of altered glutathione metabolism in ASA-induced oxidative stress, redox homeostasis and mitochondrial dysfunctions
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