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[11] Additionally, tobacco products contain numerous toxic compounds beyond nicotine, including nitrosamines and heavy metals, which may exert direct harmful effects on the liver

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PMID 40294654

Observational studies show tobacco users have higher rates of non-alcoholic fatty liver disease compared to non-users, even after adjusting for other risk factors

Whole-Body Impact of Tobacco Tobacco use introduces over 7,000 toxins into your body

The results also support the notion that nicotine increases the risk of type 2 diabetes. The researchers explained that they were unable to make corresponding analyses for women because snus use is relatively uncommon among women, but stressed this should be an important aspect of future studies