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These cells within the premetastatic niche remodel the local microenvironment by secreting inflammatory cytokines, growth factors, and proangiogenic molecules, thus supporting tumor cell colonization, proliferation, and promoting tumor metastasis 83,84,85,86,87,88

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6K, when treated with both nicotine and STATTIC, adoptive transfer of N2-neutrophils led to a significant increase in lung metastasis burden

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