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Abbreviations COPD: Chronic obstructive pulmonary disease ROS: Reactive oxygen species DAMPs: Damage-associated molecular patterns RAGE: Receptor for advanced glycation end products TLRs: Toll-like receptors MAPK: Mitogen-activated protein kinase NF-kB: Nuclear factor kappa-light-chain-enhancer of activated B cells MMPs: Matrix metalloproteinases LDL: Low-density lipoprotein NO: Nitric oxide WHO: World Health Organization SES: Socioeconomic status LGBTQ+: Lesbian, gay, bisexual, transgender, queer/questioning, and others NRT: Nicotine replacement therapy ENDS: Electronic nicotine delivery systems HTPs: Heated tobacco products PG: Propylene glycol VG: Vegetable glycerin PAHs: Polycyclic aromatic hydrocarbons FEV1: Forced expiratory volume in 1 s FVC: Forced vital capacity CT: Computed tomography ARDS: Acute respiratory distress syndrome References Addissouky TA (2019) Detecting liver fibrosis by recent reliable biomarkers in viral hepatitis patients

It also altered immune mediatorsupregulating Cxcl2 and Il-6 while suppressing Ifn- and Tgf- thereby disturbing mucosal homeostasis through concurrent shifts in microbiota, mucus composition, and cytokine signaling (Fig

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