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12 PVL has a gender predilection, with a female to male ratio of approximately 4:1, a mean age of 66 years, and a site preference for the buccal mucosa, palate, tongue, and gingivae

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While it was known previously that smoking can modulate the epigenome, it was not known how smoking influences different cell types, and whether responses would be similar or impacting different genes and biological pathways

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